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KMID : 0191120140290081170
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Journal of Korean Medical Science
2014 Volume.29 No. 8 p.1170 ~ p.1173
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Acute Pancreatitis Induced by Methimazole Treatment in a 51-Year-Old Korean Man: A Case Report
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Jung Jung-Hwa
Hahm Jong-Ryeal
Jung Jae-Hoon
Kim Soo-Kyoung
Kim Sung-Su
Kim Kyong-Young
Kim Bo-Ra
Kim Hong-Jun
Jeong Yi-Yeong
Kim Sun-Joo
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Abstract
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Methimazole (MMI)-induced acute pancreatitis is very rare but severe adverse reaction. A 51-yr-old male developed a high fever, chills, and abdominal pain, two weeks after commencement on MMI for the treatment of Graves’ disease. There was no evidence of agranulocytosis, and fever subsided soon after stopping MMI treatment. However, 5 hr after taking an additional dose of MMI, abdominal pain and fever developed again. His symptoms, biochemical, and imaging studies were compatible with acute pancreatitis. After withdrawal of MMI, he showed clinical improvement. This is the first case of MMI-induced acute pancreatitis in Korea. Clinicians should be aware of the rare but possible MMI-induced pancreatitis in patients complaining of fever and abdominal pain.
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KEYWORD
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Methimazole, Graves Disease, Pancreatitis, Drug-Related Side Effects and Adverse Reactions
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